Abstract
Flavonoids are naturally occurring phenolic compounds named as 2-phenyl-1-benzopyran-4-one and classified into several subclasses according to their basic chemical structures such as flavones,flavonols, flavanones, flavanonols, and flavanols. Among them, flavonols (3-hydroxyflavone),containing a 3-hydroxyl group in association with its 4-keto group and double bond between 2- and 3-carbon atoms, have the best electron conjugated skeleton in flavonoid family, providing several resonancestructures and chelating ability, through which various pharmacological activities such as antiviral, antitumour,anti-inflammatory, anticholinesterase, cytotoxicity and particularly high antioxidant activity aredemonstrated. They prevent generation of free radicals and are used as food preservatives. Their strongelectron conjugation provides them with fluorescent property, which make them used as imagingagents for therapeutic purpose.
Keywords: Flavonoids, flavonols, 3-hydroxyflavones, pharmacological activities, fluorescent, dye.
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Mini-Reviews in Medicinal Chemistry
Title:Recent Advances on 3-Hydroxyflavone Derivatives: Structures and Properties
Volume: 18 Issue: 2
Author(s): Burcu Butun, Gulacti Topcu and Turan Ozturk*
Affiliation:
- Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Istanbul,Turkey
Keywords: Flavonoids, flavonols, 3-hydroxyflavones, pharmacological activities, fluorescent, dye.
Abstract: Flavonoids are naturally occurring phenolic compounds named as 2-phenyl-1-benzopyran-4-one and classified into several subclasses according to their basic chemical structures such as flavones,flavonols, flavanones, flavanonols, and flavanols. Among them, flavonols (3-hydroxyflavone),containing a 3-hydroxyl group in association with its 4-keto group and double bond between 2- and 3-carbon atoms, have the best electron conjugated skeleton in flavonoid family, providing several resonancestructures and chelating ability, through which various pharmacological activities such as antiviral, antitumour,anti-inflammatory, anticholinesterase, cytotoxicity and particularly high antioxidant activity aredemonstrated. They prevent generation of free radicals and are used as food preservatives. Their strongelectron conjugation provides them with fluorescent property, which make them used as imagingagents for therapeutic purpose.
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Butun Burcu , Topcu Gulacti and Ozturk Turan*, Recent Advances on 3-Hydroxyflavone Derivatives: Structures and Properties, Mini-Reviews in Medicinal Chemistry 2018; 18 (2) . https://dx.doi.org/10.2174/1389557517666170425102827
| DOI https://dx.doi.org/10.2174/1389557517666170425102827 | Print ISSN 1389-5575 |
| Publisher Name Bentham Science Publisher | Online ISSN 1875-5607 |
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